Dados do Trabalho

Title

CAN POLYARTICULAR ULTRASOUND PREDICT THE DEVELOPMENT OF PSORIATIC ARTHRITIS OVER TIME? – A PROSPECTIVE STUDY WITH 4 YEARS OF FOLLOW-UP

Background

Articular involvement is observed in about 30% of patients with psoriasis. However, no complementary examination is sufficient to predict the risk of developing joint involvement over time.
Objectives: To evaluate the predictive value of polyarticular ultrasound (US) in patients with psoriasis, asymptomatic from the articular point of view, after 4 years of follow-up.

Materials and methods

A total of 56 patients with psoriasis (Ps) and 30 healthy controls were included in this case-control study with 2 assessments (initial time and 4 years after). Patients with previous diagnosis of any rheumatic disease were excluded. They were evaluated by dermatologist and rheumatologist to evaluate the outcomes of activity and severity of cutaneous and articular outcomes, including PASI, nail dystrophy, number of painful and swollen joints, enthesis and dactylitis. All of them performed polyarticular US by another observer, enabled in image and blinded to the other assessments.

Results

In the first evaluation, the US aggregated diagnosis of subclinial synovitis in 41% of patients with Ps, including findings of synovitis, erosion, tenosynovitis, enthesitis (P < 0.02), especially in the lower limbs (39.6% vs. 9.3% of controls). Moreover, the thickness of the tendons was higher in patients with Ps than healthy controls, regardless of the nail dystrophy (p < 0.001). After 4 years, the GUESS score (Glasgow Ultrasound Enthesitis Scoring System) was able to predict the onset of psoriatic arthritis (PsA), regardless of the nail dystrophy (P < 0.03), as well as the history of dactylitis (accuracy of 89%, specificity of 94% and HR = 17.2; 95% CI 2.2-35.7; p = 0.017) and paratendinitis of the extensor II of the toes (sensitivity of 83%, specificity of 68% and accuracy of 69.6%), after adjustments for confounding variables.

Conclusions

In patients with psoriasis, our results showed that the 2 main factors associated with the emergence of PsA, over 4 years, were the self-reported dactylitis and the US findings of the lower limbs, assessed by the GUESS score. Moreover, the higher frequency of paratendinitis of the I and II extensor of the toes was the unpublished finding of this study.

Área

Spondyloarthritis