Dados do Trabalho

Title

IS PROLONGED RANITIDINE USE ASSOCIATED WITH LOW RECURRENT ABDOMINAL PAIN IN IGA VASCULITIS?

Background

The most frequent systemic vasculitis of small vessels in childhood is Immunoglobulin A(IgA) vasculitis. The presence and intensity of abdominal pain and other gastrointestinal(GI) manifestations are criteria for both disease classification and treatment with corticosteroids. However, to our knowledge, there is no study evaluating recurrent abdominal pain associated with IgA vasculitis. Therefore, the objectives were to assess recurrent abdominal pain in IgA vasculitis patients and its relation between demographic data, clinical manifestations, and treatments.

Materials and methods

A cross-sectional retrospective study included 322 patients with IgA vasculitis(EULAR/PRINTO/PRES criteria) followed at the Pediatric Rheumatology Unit for 32 consecutive years. Sixteen patients were excluded due to incomplete data in medical charts. Recurrent abdominal pain was characterized by new abdominal pain after complete resolution.

Results

Recurrent abdominal pain was observed in 35/306(11%) in IgA vasculitis patients. The main treatment of recurrent abdominal pain included glucocorticosteroid[n=26/35(74%)] and/or ranitidine[n=22/35(63%)]. Additional analysis showed that the frequency of recurrent purpura/petechiae (37% vs. 21%,p=0.027) and the median of purpura/petechiae duration [20(3-90) vs. 14(1-270) days,p=0.014] were significantly higher in IgA vasculitis patients with recurrent abdominal pain compared to those without this complication. Gastrointestinal bleeding(49% vs. 13%,p<0.001), nephritis(71% vs. 45%,p=0.006), glucocorticosteroid use(74% vs. 44%,p=0.001) and intravenous immunoglobulin(6% vs. 0%,p=0.036) were also significantly higher in the former group. The frequency of ranitidine use was significantly higher in IgA vasculitis patients with recurrent abdominal pain versus without(63% vs. 28%,p<0.001), whereas the ranitidine duration was reduced in the former group[35(2-90) vs. 60(5-425) days,p=0.004].

Conclusions

Recurrent abdominal pain occurred in a low frequency on IgA vasculitis patients and was associated with severe clinical features. Our study suggests that ranitidine should promptly be used more than two months in IgA vasculitis with abdominal pain. Further prospective studies will be necessary to clarify this issue.