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ANKYLOSING SPONDYLITIS, ANTI-TNF AND QUALITY OF LIFE
The United Nations defines the quality of life as an "expression used to verify the needs and living conditions of human beings", based mainly on the general well-being of the individual (physical, mental, psychological and emotional). In patients with Ankylosing Spondylitis (AS), several factors alter this well-being, such as chronic pain, deformities, and functional disability. Anti-TNF therapy, since its inception, has changed the natural history of this disease. The Ankylosing Spondylitis Quality of Life (ASQol) is a nationally validated, self-applicable, specific instrument to evaluate the quality of life of patients with ASs. It is composed of 18 questions focused on the influence of the disease on its daily routine, with the highest score indicating a worse quality of life.
Materials and methods
Cross-sectional and quantitative study, with completion of the ASQol questionnaire, in addition to demographic and anti-TNF therapy related data. The study was carried out at the AS outpatient clinic of a public hospital in the city of Fortaleza. It was approved by the Ethics and Research Committee, and the free and informed consent form was answered by the participants.
The study had a total of 104 participants, 74% male and 40% white. Sixty percent were under 45 years, and 68% had been diagnosed for more than six years. Smoking was seen in 9% and alcoholism in 21% of patients. Forty-three percent were professionally active, 27% were retired, and 30% were unemployed. Eighty-six percent of patients used anti-TNF. The average of the total ASQol scores was 14 ± 5.03. In patients using anti-TNF, the mean of the ASQol scores was 9. The ASQol score was significantly associated with the variables: education (p = 0.0001), exercise (p = 0.0055) and use of anti-TNF (p = 0.0095) (Table 1).
The ASQol is an easy-to-understand, self-applicable questionnaire to evaluate the quality of life of patients with ASs. The use of anti-TNF was associated with an improvement in the quality of life of the studied sample.
Adah Sophia Rodrigues Vieira, Guilherme Lopes Pereira, João Guilherme Farias de Sá Gomes, Mariana Macedo Militão Mendonça, Clarissa Oliveira Teles, Diego Germano Maia, Rejane Maria Rodrigues de Abreu Vieira